Thrombin Generation in Chronic Liver Diseases—A Pilot Study
نویسندگان
چکیده
منابع مشابه
Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test.
Atherosclerosis is the most common pathophysiologic substrate of coronary artery disease (CAD). Whereas plaque progression and arterial remodeling are critical components in chronic CAD, intracoronary thrombosis over plaque disruption is causally related to acute CAD. It was the objective of this study to investigate the differences between prior acute CAD and chronic CAD by a simple global coa...
متن کاملThrombin activatable fibrinolysis inhibitor as a bleeding predictor in liver transplantation: a pilot observational study
OBJECTIVE To correlate the levels of thrombin activatable fibrinolysis inhibitor in the immediate postoperative period and at 24 hours postoperatively with the volume of intraoperative bleeding. METHODS Twenty-one patients allocated immediately before (elective or emergency) liver transplantation were analyzed. Blood samples were collected for thrombin activatable fibrinolysis inhibitor analy...
متن کاملDecreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis
Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or thrombotic phenotype, although they are at risk for both types of hemostatic event. Thrombin generation (TG) is a global coagulation test and its outcome depends on underlying pro- and anticoagulant processes (prothrombin conversion and throm...
متن کاملThrombin Generation in the Glasgow Myocardial Infarction Study
BACKGROUND Thrombin is a key protease in coagulation also implicated in complex pathology including atherosclerosis. To address the role of thrombin in relation to myocardial infarction (MI) we explored thrombin generation analysis in plasma from patients and controls that had participated in the Glasgow MI Study (GLAMIS). METHODS Thrombin generation at 1 and 2 pM TF and with and without thro...
متن کاملThrombin Generation in Zebrafish Blood.
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential. The zebrafish is generally accepted as a good model for human hemostasis and thrombosis, as the hemostatic system proved to be similar to that in man. Their small size however, has been a hurdle for more widespread...
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ژورنال
عنوان ژورنال: Healthcare
سال: 2021
ISSN: 2227-9032
DOI: 10.3390/healthcare9050550